中文摘要：

脑内Aβ外排至血液必须通过血脑屏障,而血脑屏障内皮细胞中的Wnt/β-catenin信号通路对血脑屏障的形成、诱导、成熟及功能具有积极的作用,血脑屏障内皮细胞中的Wnt/β-catenin信号功能失调会加速阿尔茨海默病的进程.运动能够激活脑内Wnt/β-catenin信号通路,其激活后脑细胞内β-catenin水平增加并趋于稳定,随后β-catenin进入细胞核进行转录,最终使P糖蛋白（P-glycoprotein,P-gp）表达上调.P-gp是一种重要的外排转运蛋白,可将脑内Aβ跨血脑屏障转运至血液,对预防缓解阿尔茨海默病具有重要的作用.

英文摘要：

The efflux of Aβ from brain to blood need to across the blood brain barrier,and the Wnt/β-catenin signaling pathway of BBBs endothelial cell can promote the formation,induction and maturation of BBB.The dysfunction of Wnt/β-catenin signaling pathway of BBBs endothelial cell will aggravate the process of Alzheimers disease.Exercise can activate the Wnt/β-catenin signaling pathway,and the actived signaling pathway can stabilize and increase intracellular levels of β-catenin,which induces β-catenin accumulation in the nucleus and increases its transcriptional activity,and it will increase the expression of P-glycoprotein as a result.P-glycoprotein is an important efflux transporter protein,and it can make Aβ across the blood brain barrier（BBB）to the blood,which plays an important role in preventing and ameliorating the Alzheimers disease.