中文摘要：

合成了小粒径纳米金作为卟啉保护剂,以纳米金-卟啉化合物和pH指示剂共同构建6＆#215;6传感阵列,将其用于可视化检测12种肺癌患者呼出气体中的有机小分子（ OSMs）,设置了3个浓度梯度且每个样品重复5次。实验结果显示,纳米金的引入可显著提高阵列的稳定性和灵敏度；聚类分析结果表明,5次平行实验的结果优先聚为一簇,结构相似的目标物随后聚在一起；差谱图显示该方法对不同种类、不同浓度的OSMs具有良好的定性及半定量分析能力。该方法可快速识别OSMs且具有肺癌筛查的潜在应用前景。

英文摘要：

The smaller gold nanoparticles（ AuNPs） were synthesized and used as a protectant for metal tetra-phenylporphyrins（ MTPP） , and a 6＆#237;6 sensor array was constructed together by AuNPs-MTPP compounds and pH indicators to detect 12 organic small molecules（ OSMs） in exhaled breath of lung cancer patients with three concentration gradients, and each test was repeated five times. The protective effect showed that the stability and sensitivity of the array were significantly enhanced due to the introduction of AuNPs; hierarchical cluster analysis（ HCA） indicated that the results of five parallel experiments gathered into a cluster firstly, and target objects with similar structure were gotten together subsequently;digital color difference maps of OSMs with dif-ferent kinds and concentrations visually displayed that the proposed method had good capability for qualitative and semi-quantitative analysis. The method can be used for fast identification of OSMs and has potential appli-cation prospect in lung cancer screening.