中文摘要：

目的：探讨不同训练时间的有氧运动对轻中度阿尔茨海默病（AD）患者的作用。方法：将54例AD患者随机分为有氧运动A组（18例）、有氧运动B组（18例）和对照组（18例）,有氧运动组采用踩脚踏车的运动方式,接受强度为70%最大运动能力的有氧运动训练,A组每周2h训练,B组每周1h训练,持续6个月。分别在入组前、入组3个月、入组6个月时,采用MMSE、ADAS-cog、Barthel指数、NPI和NPI-D进行AD相关评价。结果：A组有氧运动能明显改善患者的认知能力和精神神经症状,3个月和6个月时的MMSE评分从基线值19.1±3.1分别增加至21.4±2.5、24.2±1.8;ADAS-cog评分从基线值19.9±2.7分别降低至17.5±2.2、14.9±1.7;Barthel指数评分从基线值35.0±2.8分别增加至39.3±2.0、43.4±2.2;以上差异均有显著性意义（P〈0.05）。NPI评分变化值3个月时为-1.8±5.2,6个月时为-1.6±4.2,后者有显著性意义（P〈0.05）;NPI-D评分变化值3个月和6个月分别为-1.9±3.1和-1.5±2.6,两者均有显著性差异（P〈0.05）。B组仅在有氧运动早期（3个月时）可改善患者的认知功能（P〈0.05）,MMSE评分从基线值19.1±2.8增加至20.3±2.0,ADAS-cog评分从基线值20.1±2.5降低至18.3±2.5,对患者日常生活活动能力和精神神经症状无有益影响。Barthel指数与MMSE、ADAS-cog分值的变化无相关关系（r=0.136,r=0.77）。结论：6个月的每周2h的有氧运动较3个月的有氧运动在改善AD患者的认知功能、生活能力、神经精神症状以及对照顾者的困扰评分方面获益较多。

英文摘要：

Objective： To investigate the effect of aerobic exercises with different training time on mild to moderate Alzheimer＇s disease patients.Method： Fifty-four AD patients were divided into aerobic exercise group（A group and B group,18 patients separately）and control group（18 patients）.A group was trained 2h per week,while B group was trained 1h per week,the training lasted 6 months. At the beginning,third month and sixth month of aerobic exercise,every patient was evaluated with MMSE,ADAS-cog, Barthel index, NPI and NPI-D.Result： After acrobic exercise in A group patient＇s cognitive ability and mental neurological symptoms improved obviously and the difference was statistically significan（tP〈0.05）. After 3 months and 6months training,the MMSE scores from the baseline 9.1± 3.1 increased to 21.4±2.5 and 24.2±1.8 respectively, The ADAS-cog scores from the baseline 19.9±2.7 decreased to 17.5±2.2 and 14.9±1.7 respectively, BI scores from the baseline35.0 ± 2.8 increased to 39.3 ± 2.0,43.4 ± 2.2, at the end of the third month and sixth month,the changes of NPI scores were-1.8±5.2 and-1.6±4.2 respectively, compared with the baseline,the latter had significant difference（P〈0.05）, the changes of NPI-D scores were-1.9±3.1 and-1.5±2.6,both had significant differences（P〈0.05）.In B group patient＇s cognitive ability was improved just at the early phase（3 months）. There was no correlation between BI and the changes of MMSE,ADAS-cog.Conclusion： AD patients after 2h per week aerobic exercise for 6 months could get more benefits on cognitive ability,activities of daily living,mental neurological symptoms and scores of caregivers compared to 3months of aerobic exercise.