目的系统评价手术联合放射治疗腹膜后肿瘤的预后情况。方法检索Cochrane librar y、Med line、EMBASE、中国生物医学文献数据库、中国期刊全文数据库、万方等数据库,学术会议资料和学位论文,以及一些图书馆纸质出版物,全面收集关于腹膜后肿瘤外科手术联合放射治疗的相关文献。制定相应的文献排除和纳入标准,并通过复习文献制定效应指标的评价标准。由两名研究者按照相应的文献评价标准分别对收集的文献进行评价,然后应用STATA软件进行Meta分析,计算治疗组和对照组的生存率、风险率(HR)及95%CI,对不能进行Meta分析的文献进行描述性分析,客观评价各种治疗方案的疗效。结果最终共有9篇文献纳入本研究,其中中文文献1篇,英文文献8篇,累计治疗组573例,对照组1403例。Meta分析结果显示,腹膜后肿瘤手术联合放疗组患者的生存率明显高于单纯手术组(合并HR=0.57,95%CI 0.40~0.74),差异有统计学意义(P=0.000)。结论腹膜后肿瘤患者在严格完成手术的同时,可根据具体情况选择合适的方案进行放射治疗以改善预后,提高生存率。
Objective To systematic review the prognosis of radiotherapy combined with surgery for the treatment of retroperitoneal neoplasms. Methods Articles concerning randomized clinical trials(RCTs) in which radiotherapy(pre-, intraand post-operation) in combination with surgery was compared with surgery alone were retrieved by searching Cochrane Library( Jun 2014), Medline( Jan 1950–June 2014), Chinese Biomedical Literature Database( Jan 1994–Jun 2014), Chinese Science and Technology Periodicals Database( Jan 1994–Jun 2014), China National Knowledge Infrastructure( Jan 1994–Jun 2014) and Wanfang Database( Jan 1997–Jun 2014) in English and Chinese languages. The selection/inclusion criteria and exclusion criteria were ascertained by reviewing the relevant literature. The quality of data of RCTs were assessed by two researchers independently. The Stata 12.0 was used to analyze the data to calculate or extract the hazard ratio(HR) and 95%CI. Descriptive analysis was used for the articles which are not suitable for meta-analysis. Results The appropriate articles were selected. A analysis of nine articles(including 1 Chinese paper and 8 English papers) suggests that the combination of radiotherapy and surgery for RCTs is more effective than surgery alone(Merge HR=0.57, 95%CI: 0.40-0.74, P=0.000), and there was a statistically significant difference between two groups. Conclusion Retroperitoneal neoplasm patients should receive appropriate radiotherapy at the same time of surgery to improve the prognosis and elevate the survival rate.