中文摘要：

目的对海洋放线菌Streptomyces sp．LZ35固体发酵提取物的化学成分进行研究。方法采用Sephadex LH-20、硅胶等色谱柱及重结晶进行分离纯化，用波谱技术鉴定化合物的结构。结果从14L固体发酵提取物中分离得到7个安莎霉素类化合物，分别鉴定为geldanamycin（1），17—0-demethylgeldanamycin（2），herbimycinB（3），reblastatin（4），17．0-demethylreblasta—tin（5），autolytimycin（6），hygrocin Aderivative（7）。结论化合物1～7均为首次从该菌株中分离得到，且首次从一株链霉菌中分离到2种类型的安莎霉素。

英文摘要：

OBJECTIVE To study the chemical constituents of Streptomyces sp. LZ35. METHODS The constituents were isolated and purified by Sephadex LH -20 column, silicagel column and reerystallization, and their structures were identified by NMR and ESI-MS techniques. RESULTS Seven compounds were isolated and identified as geldanamycin（ 1 ） , 17-O-demethylgeldanamycin（ 2 ）, herbimycin B （ 3 ）, reblastatin（ 4 ）, 17-O-demethylreblastatin（ 5 ）, autolytimycin（ 6 ）, hygrocin A derivative （ 7 ）, respectively. CONCLUSION Compounds 1 -7 were obtained from the strain for the first time. Two types of ansamyeins were isolated for the first time from Streptomyces sp.