中文摘要：

DNA甲基化是目前肿瘤领域研究中研究最多的表观遗传学机制之一.主要发生在DNA的CpG岛.DNA的甲基化通过甲基转移酶（DNA methyltransfeases,DNMTs）完成.DNA甲基化在多种肿瘤的发生、发展中都起到了重要的作用.大量研究发现,甲基化与多发性骨髓瘤的发生、发展及诊断治疗等有密切关系.深入探讨多发性骨髓瘤（MM）相关的甲基化可为MM发病机制的研究及治疗提供新的思路.

英文摘要：

DNA methylation is one of the most widely studied epigenetic events in tumor research. DNA methylation usually occurs at CpG island. DNA methylation is mediated by DNA methyltransfeases （DN- MTs）. DNA methylation plays an important role in the development and progression of lots of cancers. A great number of studies had indicated a strong correlation between the multiple myeloma （MM） and methyla- tion. Further studies on the MM associated methylation may provide new sights into MM pathogenesis and its diagnosis and treatment.