中文摘要：

目的：比较帕米膦酸二钠与唑来膦酸治疗肺癌骨转移性疼痛的近期疗效、不良反应及其对于患者住院时间及住院费用的影响.方法：将40例确诊肺癌骨转移患者随机分为2组：帕米膦酸二钠组（20例）、唑来膦酸组（20例）.帕米膦酸二钠注射液60mg,加入500ml生理盐水内,静脉滴注4h;唑来膦酸注射液4mg,加入100ml生理盐水内,静脉滴注20min.两组均每4周给药1次,共2次给药.比较2组患者的疼痛控制效果、血碱性膦酸酶（AKP）、血钙的变化、平均住院时间及总住院费用.结果：帕米膦酸二钠、唑来膦酸组的获益率分别为90％及85％,不良反应发生率无明显差异,均未发生下颌骨坏死.2组治疗后AKP及血钙均明显下降（P＜0.05）.2组病人的住院时间（P＞0.05）及住院费用无明显差异（P＞0.05）.结论：帕米膦酸二钠与唑来膦酸应用于本研究中的肺癌病人,在疗效、不良反应及成本效益方面均无明显差异.

英文摘要：

Objective：To compare the short-term efficacy and side-effects of Zoledronic acid and Pamidronate disodium in treatment of patients with bone metastatic lung cancer.Methods：All 40 patients diagnosed as lung cancer with bone metastasis were divided randomly into the Pamidronate disodium group （20 cases） and Zoledronic acid group （20 cases）.Administration method：60mg Pamidronate disodium added into 500ml saline was administered in intravenous infusion for 4 hours and 4mg Zoledronic acid added in 100ml saline within 20 minutes,and both of them were administered every 4 weeks for 8 weeks.The short-term efficacy and side-effects of Zoledronic acid and Pamidronate disodium,as well as their influences on hospitalization expenses and hospital stays were evaluated.Results：The overall response rates of Pamidronate disodium and Zoledronic acid groups were 90% and 85 %,respectively.Side effects included fever and hypocalcemia.No patients suffered osteonecrosis of the jaw.In both groups,alkaline phosphatase （AKP） and serum calcium decreased significantly after treatment （P 〈 0.05）.Moreover,there were no significant differences of hospitalization expenses and hospital stays between the two groups （P 〉 0.05）.Conclusion：There were no differences in short-term efficacy,side effects or cost-effectiveness between the two drugs.