中文摘要：

肝性脑病（HE）是由各种急、慢性肝病引起的一种严重的并发症,可表现为行为异常、意识障碍,甚至昏迷,对病人生活质量及预后的影响非常大;轻微型肝性脑病（MHE）无明显的临床表现,易被忽视,但病人存在认知功能等障碍,工作能力及生活质量受到影响。HE的神经病理学机制仍不明确。近年来功能MR成像（functionalMRI,fMRI）技术有了较大进展,并被用于研究HE的神经病理学机制。就近年来HE神经病理学机制的fMRI研究作一综述。

英文摘要：

Hepatic encephalopathy （HE）, characterized by a wide spectrum of clinical manifestations, ranging from behavior abnormality, conscious disorder and even coma, is a consequence of liver dysfunction in both acute and chronic hepatic diseases. Minimal hepatic encephalopathy （MHE） refers to a subgroup of cirrhotic patients without clinical overt hepatic encephalopathy symptoms but with abnormalities in neuro -cognitive functions. HE/MHE can have a far -reaching impact on quality of life and prognosis. The exact neuropathology mechanism was still unclear. Recently, functional MRI （fMRI） has been increasingly applied for investigating the neuro-pathophysiological mechanism of HE. This paper will review the fMRI research applied on uncovering the neuropathology mechanism of HE.