中文摘要：

目的：探讨甲硝唑联合乳酸杆菌治疗妊娠期滴虫性阴道炎患者的临床疗效。方法：将本院妇科门诊收治的88例妊娠期滴虫性阴道炎患者分为联合组和对照组各44例,两组患者均给予甲硝唑片口服治疗,联合组加用乳酸杆菌胶囊治疗,比较两组患者治疗1个疗程（甲硝唑连用7d,乳酸杆菌胶囊连用10d为1个疗程）后的临床疗效差异。结果：联合组的治疗总有效率为90.91%显著高于对照组的75.00%且差异具有统计学意义（P〈0.05）。治疗后两组患者的IL-8、IL-13较治疗前均显著降低（P〈0.05）,联合组降低更加显著（P〈0.05）,治疗前后两组患者的IL-2变化不显著（P〉0.05）。治疗1个疗程结束时,联合组的阴道滴虫转阴率97.73%高于对照组的93.18%但差异不具有统计学意义（P〉0.05）。治疗结束1个月后,联合组的滴虫转阴率95.45%显著的高于对照组的81.82%且差异具有统计学意义（P〈0.05）。治疗1个疗程结束时,联合组的乳酸杆菌菌落数≥1/2面积率为75%显著高于对照组的22.73%且差异具有统计学意义（P〈0.05）,联合组的产H2O2阳性率47.73%显著的高于对照组的15.91%且差异具有统计学意义（P〈0.05）。结论：甲硝唑联合乳酸杆菌治疗妊娠期滴虫性阴道炎患者对于恢复患者阴道微生态环境、提高治疗效果具有显著作用。

英文摘要：

Objectives：To explore the curative effect of metronidazole combined with lactobacillus in the treatment of trichomonal vaginitis patients in pregnancy.Methods：88 trichomonal vaginitis patients in pregnancy in the gynaecology outpatient of our hospital were divided into combination group and control group,44 cases in each group.Both groups were given metronidazole 200 mg,tid,in vaginal placement,and the combination group received additional lactobacillus capsule.The clinical efficacy of the two groups was compared after a treatment course（ metronidazole QD for 7d,lactobacillus capsule for 10 days for a course of treatment）.Results：The total effective rate in the combination group was 90.91%,significantly higher than that of the control group（ 75%）,with statistically significant difference（ P 0.05）.The IL-8 and IL-13 in the two groups after treatment were significantly lower compared with those before treatment（ P 〈0.05）,more significant in the combination group（ P 〈0.05）.Difference in IL-2 before and after treatment in two groups was not significant（ P〈 0.05）.At the end of a course of treatment,the vaginal trichomonad negative rate in combination group was 97.73%,higher than that of 93.18% in the control group but the difference was not statistically significant（ P 〉0.05）.1 month after treatment,the trichomonad negative rate in observation group was 95.45%,significantly higher than the control group of 81.82% and the difference was statistically significant（ P〈 0.05）.At the end of a course of treatment,the lactobacilli colony number not less than 1/2 area rate was 75% in the observation group,significantly higher than control group of22.73% and the difference was statistically significant（ P〈 0.05）;the H2O2 positive rate in observation group was47.73%,significantly higher than control group 15.91%,with statistically significant difference（ P 0.05）.Conclusions：Metronidazole combined with lactobacillus in the treatment of trichomonal vaginitis patients in p