中文摘要：

以铜纳米颗粒作为催化剂,Cs2CO3为碱,二卤甲烷为底物和溶剂,发展了一个高效的催化炔、二卤甲烷、胺三组分偶联反应（AHA偶联反应）生成炔丙胺的反应体系.与文献相比,该催化体系具有催化剂廉价易得、反应条件相对温和、底物适应性优良、使用单一溶剂体系后处理方便的特点.同时,以铜纳米颗粒为催化剂,易于实现催化剂的有效循环利用,经5次反应催化活性未见明显下降.

英文摘要：

A copper nanoparticles-catalyzed three-component coupling reaction of alkyne, dihalomethane, and amine （ALIA coupling） was reported for the synthesis of propargylic amine. The catalytic AHA coupling reaction was carded out under mild conditions with dihalomethane as substrate and solvent, and good to excellent yields were also achieved. Furthermore, the nanopartiele catalyst could be recovered and reused effectively, and no obvious reduction on catalytic activity was observed for five recycles.