中文摘要：

miRNA是真核生物内源性基因编码的、长度约为22 nt的单链RNA,它主要通过与目标m RNA的3′端相结合,在翻译水平调控基因的表达。近年来发现,miRNA在类风湿性关节炎中与细胞的异常增殖、侵袭、凋亡等相关,并可参与局部病灶的免疫反应。现将对miRNA在类风湿性关节炎中表达、功能和如何参与调控免疫反应作一综述。

英文摘要：

MiRNAs are endogenous, non-coding, single-stranded RNAs with about 21 nucleotides in length. They are known as post-transcriptional regulators by binding to 3＇-untranslated region of their target genes. Recently, it has been shown that miRNA was associated with the pathogenesis of rheumatoid arthritis （RA） in various aspects, such as chronic inflammation and hyperplasia in the synovial lining cells. The purposes of this review are to provide an overview on our current understanding of miRNA expression and function in RA and to underscore the potential for clinical application of miRNAs in RA.