中文摘要：

目的：研究血清抵抗素（SR）水平与2型糖尿病（T2DM）合并高血压患者血压的相关性。方法：选择T2DM合并高血压患者（T2DM合并高血压组）124例，单纯T2DM患者（单纯糖尿病组）85例，正常对象（正常对照组）71例纳入研究。根据血压水平，T2DM合并高血压组被进一步分为1级亚组（34例），2级亚组（43例）和3级亚组（47例）。取外周静脉血测量三组SR及其他指标水平。L0gistic多元回归分析用来分析影响血压水平的危险因素。Kendall’s tau-b相关分析用来分析SR，空腹胰岛素，量化胰岛素敏感指数和胰岛素抵抗指数与血压水平的相关性。结果：与健康对照组比较，单纯糖尿病组和T2DM合并高血压组SR水平显著升高[（7．21±Z．65）ng／ml比（19．87±3．67）ng／ml比（31．32±3．89）ng／m1]，且T2DM合并高血压组的显著高于单纯糖尿病组的（P均〈0．01）。Logistic多元回归分析表明SR水平是影响患者血压水平的独立危险因素（R2=0．087，P〈0．05）。Kendall’s tau-b相关分析显示SR水平与高血压患者血压水平呈显著正相关（r=0．202，P=0．001）；控制其余影响因素后，二者间仍然呈显著正相关（r=0．233，p=0．022）。结论：血清抵抗素水平是2型糖尿病合并高血压患者的危险因素，与其血压水平呈显著正相关。

英文摘要：

Objective： To study the correlation between serum resistin （SR） level and blood pressure in patients with type 2 diabetes mellitus （T2DM） complicated hypertension. Methods： A total of 124 patients with T2DM complicat- ed hypertension （T2DM ＋ hypertension group）, 85 patients with pure T2DM （pure DM group） and 71 normal sub- jects （normal control group） were enrolled. According to blood pressure level, T2DM ＋ hypertension group was further divided into stage 1 subgroup （n=34）, stage 2 subgroup （n=43） and stage 3 subgroup （n=47）. Peripheral venous blood was taken to measure levels of SR and other indexes in three groups. Logistic multi-factor regression a- nalysis was used to analyze the risk factors affecting blood pressure level. Kendall＇s tau-b correlation analysis was used to analyze the correlation among SR, fasting insulin, quantitative insulin sensitivity check index, homeostasis model-insulin resistance index and blood pressure level. Results： Compared with normal control group, there were significant rise in SR levels [ （7.21±2.65） ng/ml vs. （19.87±3.67） ng/ml vs. （31.32±3.89） ng/ml] in pure DM group and T2DM ＋ hypertension group, and that of T2DM ＋ hypertension group was significantly higher than that of pure DM group, P〈0. 01 all. Logistic multi-factor regression analysis indicated that SR level was an independent risk factor influencing blood pressure level of patients （R^2= 0. 087, P〈0.05）. Kendall＇ s tau-b correlation analysis indicated that SR level was significantly positively correlated with blood pressure level of patients with hypertension （r = 0. 202, P = 0. 001） ; after other influencing factors were controlled, the significant positive correlation still exis- ted between them （r=0. 233, P=0. 022）. Conclusion： Serum resistin level rise is risk factor of patients with type 2 diabetes mellitus complicated hypertension, and it significantly positively correlated with their blood pressure level.