中文摘要：

卵巢癌是严重威胁女性生殖健康的肿瘤之一,死亡率居各类妇科肿瘤的首位。上皮性癌是卵巢癌中最常见的病理类型,近年来虽然手术及放化疗技术不断提高,但75%~80%晚期患者在治疗后仍出现复发或进展。多药耐药是导致上皮性卵巢癌治疗后复发、转移和死亡的重要原因,严重制约上皮性卵巢癌患者生存率的提高。信号传导通路是多药耐药的重要调控机制之一,目前对其作用机制的研究取得了一定进展,其靶向药物亦在临床各期试验获得了良好效果。本文拟对信号传导通路在上皮性卵巢癌多药耐药机制及目前相关靶向药物在临床研究进展进行综述,为其进一步在临床应用提供指导价值。

英文摘要：

Ovarian cancer is a serious threat to women＇s reproductive health. Epithelial carcinoma is the most common pathological type of ovarian cancer. In addition, epithelial carcinoma demonstrates the highest mortality among all types of gynecological tumors.Despite the recent advances in surgery, radiation, and chemotherapy, recurrence or deterioration still occurs in 75%–80% of patients after treatment. Multidrug resistance is a major cause of post-treatment relapses, metastasis, and even death. This characteristic severely restricts the survival of patients with epithelial ovarian cancer. Signaling pathways are important regulatory mechanisms of multidrug resistance. To date, research on the mechanisms of action of these pathways has progressed, and clinical trials on specific inhibitors obtained satisfactory results. This study explores the potential relationship between signaling pathways and multidrug resistance in epithelial ovarian cancer, as well as the current progress in clinical research on targeted drugs, to provide a theoretical basis for clinical applications.