中文摘要：

目的基于下丘脑-垂体-肾上腺轴内分泌环的调控影响骨质变化理论基础，建立肾上腺功能低下动物模型，研究肾上腺功能低下及补充肾上腺皮质激素对骨组织的影响。方法使用SD大鼠进行肾上腺次全切除手术，建立肾上腺功能低下动物模型。给予动物模型不同剂量糖皮质激素替代治疗，研究其对骨组织的影响。结果手术后大鼠出现了肾上腺功能低下状态。小剂量激素替代治疗后检测指标显示恢复性变化，大剂量激素治疗无明显改善。股骨生物力学实验提示骨力学综合能力指标下降。结论①肾上腺功能变化伴有骨代谢改变，骨组织形态计量学变化先于骨生物力学；②利用肾上腺次全切除后给予糖皮质激素替代治疗，可以造成骨质疏松；③糖皮质激素具有双重作用，小剂量激素替代治疗有助于修复骨质的损伤，大剂量糖皮质激素对骨质有损伤或加重损伤的作用；④肾上腺功能低下性骨质疏松生物力学变化是力学综合能力降低。

英文摘要：

Objective On the basis of the theory of endocritic axis of hypothalamuls-pituitary-adrenal, the animal models of hypoadrenia have been built. The influence on the bone by the hypoadrenia and suppling cortical hormone have been studied. Methods SD rats have been chosen and the subtotal adrenalectomy has been performed. Then the pathological model of rat has been obtained with hypoadrenia and the treatments of different doses have been done and the impact on the bone of rats has been studied. Results The hypoadrenia have been found on the rats after the operation. The targets of the hormone treatments of small doses show recovery while the targets of the hormone treatments of large doses show no change. The biomechanical experiments show that the comprehensive targets of mechanics have decreased. Conclusions （1）The change of adrenal function follows the change of the osteometabolism. The change in osteomorphokinetics occurs earlier than the change in biomechanics. （2）The new model induces osteoporosis. （3）There are double functions in the glucocorticoid. One is that the small doses of hormone benefit the restoration of bone and the other is that the large doses of hormone damage the bone. （4）The change in the biomechanics of hypoadrenia induced osteoporosis is the decrease of comprehensive mechanics.