中文摘要：

目的研究小剂量缓激肽对大鼠脑血管内皮细胞和C6细胞钙激活钾电流的作用。方法应用膜片钳全细胞记录模式。结果指令电位为＋60mV时。1μmol·L^-1缓激肽可使大鼠脑血管内皮细胞和C6细胞钙激活钾电流分别由给药前的（770±220）pA和（630±220）pA降至给药后的（370±40）pA和（308±19）pA（n=6，P〈0．01）。结论小剂量的缓激肽通过抑制脑微血管内皮细胞和C6细胞的钙激活性钾电流，引起细胞的去极化。

英文摘要：

Objective To investigate the effect of bradykinin by recording calcium-activated potassium currents on rat＇ s brain microvascular endothelial cells and C6 cells. Methods Standard whole cell recording method was used. Results At potential of ＋ 60 mV, calcium-activated potassium currents were decreased from （ 770 ± 220 ） pA and （630 ± 220 ） pA to （ 370 ± 40 ） pA and （308 ± 19） pA（ n = 6, P 〈 0.01 ） on rat＇ s brain microvascular endothelial cells and C6 cells, respectively, after the administration of bradykinin （ 1μmol· L^-1 ）. Conclusions Bradykinin can depolarize rat＇s brain microvascular endothelial cells and C6 cells through the inhibition of calcium-activated potassium channels.