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芯片上单链DNA生物膜的弯电性能分析
  • 期刊名称：材料工程
  • 时间：0
  • 页码：11-14
  • 语言：中文
  • 分类：Q66[生物学—生物物理学] R318.01[医药卫生—生物医学工程;医药卫生—基础医学]
  • 作者机构：[1]上海市应用数学和力学研究所上海市力学在能源工程中的应用重点实验室,上海200072, [2]上海大学理学院力学系,上海200444
  • 相关基金：国家自然科学基金（10872121）; 上海市教育委员会科研创新项目（09YZ07）; 国家杰出青年基金（10725209）; 上海市重点学科建设（S30106）
  • 相关项目：DNA-微悬臂梁纳米力学行为的研究
作者： 李晶晶|徐凌伟|张能辉|陈建中|
关键词： DNA生物膜, 电势, 变形, 弯电效应, 非线性Poisson-Boltzmann方程, DNA biofilm, electrostatic potential, deformation, flexoelectric effect, nonlinear Poisson-Boltzmann equation
中文摘要：

基于非线性Poisson-Boltzmann（NLPB）方程和液晶薄膜弯电理论,利用Fogolari修正公式,建立了单链DNA（ss-DNA）分子结构特征、溶液离子浓度等因素与生物膜电势、芯片宏观变形之间的非线性多尺度关系。结合现有的实验数据,拟合了单链DNA生物薄膜的弯电系数,并将生物膜电势分布及芯片变形的线性预测和非线性预测进行了比较,阐明了非线性多尺度关系的有效性。考察了DNA链片断数和封装密度等因素对芯片变形的影响。结果表明：随着DNA链片断数和封装密度的增加,芯片变形逐渐增加。

英文摘要：

Based on nonlinear Poisson-Boltzmann equation（NLPB） and flexoelectric theory of liquid crystal thin films,with the help of Fogolari＇s correct formula,a nonlinear multiscale relation among single-stranded DNA（ssDNA） molecule structure feature,salt solution concentration and biofilm electrostatic potential,chip macroscopic deformation is formulated.The flexoelectric coefficient is obtained by curve fitting based on existing experimental data.The linear and nonlinear predictions for biofilm electrostatic potential and chip deformation are compared to validate the present nonlinear multiscale relation.The influences of DNA fragment length,packing density on chip deformation are also investigated.The results show that chip deformation increase with the enhancement of DNA fragment length and packing density.

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