细胞外基质磷酸糖蛋白(MEPE)是一种细胞外基质的非胶原性磷酸化糖蛋白,主要表达于骨组织、牙组织和肾近球小管中,在骨形成矿化以及调节磷吸收方面发挥重要作用。酸性丝氨酸-天冬氨酸-富集细胞外基质磷酸糖蛋白相关性基序与细胞外基质磷酸糖蛋白活性片段/AC-100多肽是MEPE的重要结构域,其生物学功能是近来研究的热点。
Matrix extracelluar phosphoglycoprotein (MEPE), which is one of the matrix extracelluar non-collage- nous proteins, is expressed in bone, teeth and renal proximal convoluted tubules. It is considered to be a potential phosphatonin. And it plays an important role in bone formation and mineralization. ARASM fragments and dentonin/AC-100, motifs derived from MEPE, are the focus of recent research.