中文摘要：

目的 探讨肿瘤坏死因子-β（tumor necrosis factor-β，TNF-β）基因G252A多态性与精神分裂症、心境障碍是否关联。方法 收集65个核心家系，采用PCR-RFLP技术对G252A多态性基因分型，进行传递不平衡检验。结果在女性组（X^2=5．26，10=1，P〈0．05）和发病年龄≤25岁早发组（X^2=6．76，10=1，P〈0．01），G252A多态性与精神分裂症相关联；在早发组（X^2=5．00，10：1，P〈0．05）G252A多态性与心境障碍相关联，无性别差异（P〉0．05）。结论 在中国汉族人群中TNF-β基因可能是精神分裂症和心境障碍的共同易患基因之一，并可能影响发病年龄。

英文摘要：

Objective To explore the relationships between TNF-β gene polymorphism G252A and schizophrenia, mood disorders in the mixed pedigrees of Chinese Han population. Methods Collected 65 core families, the G252A polymorphism was genotyped by applying PCR-RLFP technique, then transmission disequilibrium test （TDT）＇was performed. Results TNF-β gene polymorphism G252A was associated with schizophrenia in female group （ Z2 = 5.26,v = 1, P 〈 0.05 ） and early-onset （ age of onset ≤ 25 years ） group （ X^2 = 6.76, V = 1, P 〈 0.01 ）. The G252A polymorphism was associated with mood disorders in early-onset group（ X^2 = 5.00 ,V = 1, P 〈 0.05）. Conclusion TNF-β gene may be one of common susceptible genes for schizophrenia and mood disorders in Chinese Han population, also may affect the age of onset.