中文摘要：

目的：探讨血浆抵抗素水平与肥胖间的关系。方法：2005年对北京市石景山区1258例研究对象（其中男性439例，女性819例）进行流行病学调查，系统收集吸烟、饮酒、体力活动、血压、血脂、血糖、体重、腰围等心血管病危险因素资料，并采用酶联免疫吸附法测定研究人群血浆抵抗素水平。结果：同时按照腰围（男性〈85cm、85～90cm、≥90cm，女性〈80cm、80～85cm、≥85cm）和体重指数（BMI〈24kg／m^2、24～28kg／m^2、≥28kg／m^2）分别比较各自的血浆抵抗素水平。结果显示，无论男性还是女性，随着BMI和（或）腰围增加，血浆抵抗素水平显著升高；男性BMI〈24kg／m^2、腰围〈85cm者血浆抵抗素水平最低，而BMI≥28kg／m^2、腰围≥90cm者血浆抵抗素水平最高，两者血浆抵抗素水平的中位数分别为1．66ng／ml和3．41ng／m1（P〈0．001）；女性BMI〈24kg／m^2、腰围〈80cm者血浆抵抗素水平最低，而BMI≥28kg／m^2、腰围≥85cm者血浆抵抗素水平最高，两者血浆抵抗素的中位数分别为2．06ng／ml和3．81ng／ml（P〈0．001）。多元线性回归分析的结果显示，即使在控制了年龄、吸烟、饮酒、饮茶、体力活动、血压、血脂、高敏C反应蛋白的情况下，无论男性还是女性，血浆抵抗素水平与腰围和体重指数之间均存在显著的关联。结论：本研究显示血浆抵抗素水平和肥胖之间存在密切关联，然而由于本研究为横断面关联研究，其研究结果仍有待进一步的研究进行证实。

英文摘要：

Objective：To explore the relationship between plasma resistin level and obesity. Methods：A community based epidemiology survey was carried out in a population of 1258 subjects including 439 male and 819 female at Shijingshan, Beijing in 2005. The subjects were divided into different groups according to the body mass index （BMI 〈 24 kg/m2 ,24- 28 kg/m2 and /〉28 kg/m2） and the waist circumference （male： 〈 85 cm,85 -90 cm and t〉90 cm; female： 〈 80 cm, 80 -85 cm and 1〉85 cm）. The plasma resistin level was examined by ELISA. The risk factors for cardiovascular diseases as smoking, drinking, physical activity, blood pressure （BP） and body weight were collected, serum total cholesterol （TC） , high density lipoprotein cholesterol （ HDL-C）, triglyceride （TG） , fasting glucose, high sensitivity C reactive protein （hs-CRP） were measured in each group respcetivcly. Results：The plasma level of resistin elevated accordingly with the increased BMI and/or waist circumference in both male and female. In male subjects, BMI 〈 24 kg/m^2, the waist circumference 〈 80 cm had the lowest plasma resistin, while BMI≥ 28 kg/m^2, waist circumference ≥90 cm showed the highest plasma resistin,the median value of resistin in those two groups were 1.66 ng/ml and 3.41 ng/ml （ P 〈 0. 001 ）. In female subjects, BMI 〈 24 kg/m2, waist circumference 〈 80 cm had the lowest plasma resistin, while BMI ≥ 28 kg/m^2, waist circumference≥ 85 cm showed the highest plasma resistin. The median value for these two groups were 2. 06 ng/ml and 3.81 ng/ml （P 〈 0. 001 ）. After controlling the age, drinking, physical activity, BP, TC, HDL-C ,TG, fasting glucose and hs-CRP, the relationship between plasma resistin level and BMI/waist circumference were still significant for both male and female. Conclusion：Our study indicated that plasma resistin level closely related to obesity, further investigation will be continued.