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聚环氧乙烷-g-聚己内酯两亲性接枝共聚物的合成及药物释放行为
  • ISSN号：0251-0790
  • 期刊名称：《高等学校化学学报》
  • 时间：0
  • 分类：O631[理学—高分子化学;理学—化学]
  • 作者机构：[1]中国科学院化学研究所,北京100190, [2]中国科学院研究生院,北京100049
  • 相关基金：基金项目：国家自然科学基金（批准号：50830103,50521302）资助.
作者： 毛静[1,2], 甘志华[1]
关键词： 两亲性接枝共聚物, 聚环氧乙烷, 聚己内酯, 自组装, 药物释放, Amphiphilic graft copolymer, Poly （ ethylene oxide ） , Poly （ ε-caprolactone ） , Self-assembly, Drug release
中文摘要：

通过环氧丙醇（GL）与环氧乙烷（EO）的阴离子顺序开环聚合制备了水溶性嵌段共聚物PEO—b—PGL，以PGL嵌段每个重复单元的侧羟基为引发点进一步引发ε-己内酯（cL）的开环聚合，合成了结构规整的以聚环氧乙烷（PEO）为主链的两亲性接枝共聚物（PEO—b—PGL—g—PCL）．研究了PEO—b—PGL—g—PCL在水相中的自组装行为，采用稳态荧光探针法测定了胶束的临界胶柬浓度（cmc）．以疏水性药物阿霉素（DOX）为模型药物，研究了两亲性接枝共聚物的化学组成对药物的扩散释放以及降解释放行为的影响．

英文摘要：

Water-soluble diblock copolymers PEO-b-PGL with well controlled composition were synthesized by sequential anionic ring-opening copolymerization of ethylene oxide （EO） and glycidol （GL）.ε-Caprolactone （CL） was further initiated by the pendant hydroxyl group of each GL unit in PEO-b-PGL copolymer to synthe- size amphiphilic graft copolymers PEO-b-PGL-g-PCL with well defined grafting architecture. The self-assembly died. The influences of composition and grafting structure in PEO-b-PGL-g-PCL copolymers on self-assembly, drug loading and release were discussed.

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期刊信息
  • 《高等学校化学学报》
  • 北大核心期刊（2011版）
  • 主管单位:中华人民共和国教育部
  • 主办单位:吉林大学 南开大学
  • 主编：周其凤
  • 地址：吉林大学南胡校区
  • 邮编：130012
  • 邮箱：cjcu@jlu.edu.cn
  • 电话：0431-88499216
  • 国际标准刊号：ISSN：0251-0790
  • 国内统一刊号：ISSN：22-1131/O6
  • 邮发代号:12-40
  • 获奖情况:
  • 首届及第二届国家期刊奖,连续两届“百种中国杰出学术期刊”,中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国工程索引,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:50676