中文摘要：

目的：探讨慢性创伤后应激障碍（post-traumatic stress disorder,PTSD）患者脑功能激活特征。方法：对17例矿难相关的慢性PTSD患者和14例经历相同矿难未患病的对照进行脑功能磁共振成像。使用Matlab6.5和SPM2软件对功能磁共振数据进行处理。结果：与对照组相比,患者组左海马旁回激活增强;右楔前叶激活降低。与中性图片相比,患者组面对负性图片时右海马旁回、右梭状回、右枕下回、双侧枕中回的激活增强;左顶下小叶、左顶上小叶、右中央后回、左楔叶、背外侧前额叶的激活降低。对照组面对负性图片时,右楔前叶激活增强;右岛叶激活降低。结论：这些脑区改变可能反映了PTSD患者症状包括对创伤情绪和记忆加工不足的复杂的生物学机制。

英文摘要：

Objective：To study the features of brain functional activation in patients with chronic post-traumatic stress disorder（PTSD）.Methods：Seventeen miners with chronic PTSD resulting from a severe mining accident and 14 miners exposed to the same accident without PTSD underwent functional magnetic imaging（fMRI）.Results：The PTSD group showed greater activation in left parahippocampal gyrus and lower activation in right precuneus than non-PTSD controls.As compared with the control group,the PTSD group showed greater activations in right parahippocampal gyrus,right fusiform gyrus,right inferior occipital gyrus,bilateral middle occipital gyri in response to negative pictures;and lower activation in left inferior parietal gyrus,left superior parietal gyrus,right postcentral gyrus,left cuneus,dorsolateral prefrontal gyrus than in response to neutral pictures.The non-PTSD controls showed greater activation in right precuneus and lower insular in response to negative pictures,than in response to neutral pictures.Conclusion：The change of the brain may reflect complex biological mechanism of PTSD symptoms,including insufficient processing of traumatic emotion and memory.