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中文摘要：
业已明确，细胞骨架重排发生在多种细胞生命活动中，使细胞质在凝胶态和溶胶态之间转换。这一可逆性过程涉及多种蛋白质，其中凝溶胶蛋白（gelsolin）超家族通过切断肌动蛋白丝、脱离肌丝终端、促进肌动蛋白聚集成核等方式控制肌动蛋白的构建，使肌动蛋白在单体和聚合体两种形式问通过聚合解聚作用维持动态平衡…。凝溶胶蛋白作为凝溶胶蛋白家族的成员之一，能够与肌动蛋白结合并且调节肌动蛋白的聚合解聚作用，是一种重要的肌动蛋白结合蛋白，也是目前研究较为详尽和透彻的重要蛋白分子。其主要功能包括调节肌动蛋白活性、细胞运动、细胞凋亡、吞噬功能以及血小板的形成和活化等。许多研究表明，
英文摘要：
Gelsolin is an important actin -binding plasma protein, with modulation of actin dynamics through binding, severing and capping actin filaments, which can be regulated by Ca^2＋ , pH and phosphatidylinositol, etc. Multitude complex functions of gelsolin have been involved in various cellular processes, including regulation of actin dynamics, cell motility, phagocytosis, control of apoptosis, platelet formation and activation. Gelsolin plays a pivotal role in the pathogenesis of apoptosis, blood clotting, immunity, tumor and inflammation. This review will focus on the advances in the structure, function as well as mechanism of actions of gelsolin, and provide a basis for reflection on other possible and as yet incompletely understood roles in clinic.
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