中文摘要：

端粒DNA结合蛋白TRF2（TTAGGG repeat binding factor-2）以二聚体形式通过Myb结构域与端粒重复序列TTAGGG结合,并与TRF1、TIN2、Rap1、TINT1及POT1蛋白组成Shelterin蛋白复合物,协同在端粒动态平衡维持过程中起关键作用,进而影响整个基因组的稳定性.此外,TRF2在细胞DNA损伤应答过程中可能发挥重要作用.本文将对TRF2结构和功能研究的最新进展进行综述.

英文摘要：

TRF2 （TTAGGG repeat binding factor-2） is a telomere-related protein. Dimerized TRF2 proteins bind to the telomere repeat squence TTAGGG via their Myb motif. TRF2, TRF1, Rapl, TIN2, TINT1 as well as POT1 assemble a protein complex called shelterin and cooperate to play key roles in maintaining the homeostasis of telomeres. TRF2 not only functions on modeling telomere morphology, controlling telomere length and protecting 3＇ G-rich overhang, but also regulates the stability of genome. Beyond telomere, TRF2 could be involved in DNA damage response system when telomeric or non-telomeric DNA damage occurrs in cells.