中文摘要：

线粒体是一种重要的细胞器,时刻处在分裂和融合的动态循环中,通过动力学过程发挥其功能。打破线粒体动力学平衡会导致线粒体功能出现障碍,如ATP产生减少,活性氧物质累积等,这些都与阿尔茨海默病发病密切相关。阿尔茨海默病患者的一大重要病理特征是β淀粉样蛋白沉积,有研究表明β淀粉样蛋白参与并影响了线粒体动力学的调控。因此研究线粒体动力学分裂融合的调控机制,尤其是线粒体分裂与β淀粉样蛋白之间的关系有助于找到治疗阿尔茨海默病的新方法。本文主要综述了线粒体动力学调控的分子机制及其与β淀粉样蛋白之间的关系,以期为未来阿尔茨海默病治疗药物研究提供新的思路。

英文摘要：

Mitochondria are an important organelle which is always in the dynamic cycle of fission and fusion,and exerts normal functions through this process.The disruption of mitochondrial dynamic balance might lead to mitochondrial function disorders such as reduction of ATP production and accumulation of reactive oxygen species,which are associated with the etiology of Alzheimer＇s disease.β-Amyloid accumulation is an important pathologic feature of Alzheimer＇s disease.Studies have shown that β-amyloid is involved in the regulation of mitochondrial dynamics.Therefore,studying the mechanism of mitochondrial fission and fusion as well as its relationship withβ-amyloid may help us find a new direction for the treatment of Alzheimer＇s disease.In this review,we summarized the molecular mechanisms of mitochondrial dynamics and the relationship with β-amyloid,which might give new thoughts for new drug development.