中文摘要：

在这研究，我们在肿瘤在 ovariectomized athymic 老鼠植入的雌激素依赖者人乳癌(MCF-7 ) 的生长上探索了酱油 isoflavone 摘录的效果。ovariectomized athymic 老鼠与 MCF-7 房间被植入。他们分别地用酱油 isoflavone 摘录的低、中等、高的剂量被喂，在 6.25， 12.5 和 25 g/kg 的饮食的集中。ki-67 的表示被免疫组织化学检测。在肿瘤的 pS ₂ 表示被即时 PCR 分析。在浆液的雌激素水平被化合光酶免疫分析测量。与控制组相比，饮食的酱油 isoflavone 摘录在老鼠在 MCF-7 肿瘤生长上有重要 stimulatory 效果(P 【 0.05 ) 。在肿瘤的 ki-67 和 pS ₂ mRNA 表情被酱油 isoflavone 摘录的 6.25 和 12.5 g/kg 剂量显著地增加(P 【 0.05 ) 。并且，在 6.25 和 12.5 个 g/kg 剂量组的浆液的雌激素水平比控制组的高(P 】 0.05 ) 。在结论，在测试饮食的集中范围酱油 isoflavone，摘录在肿瘤生长上有 stimulatory 效果。酱油 isoflavone 摘录的 6.25 和 12.5 g/kg 剂量能在肿瘤增加房间增长并且导致雌激素应答的 pS2 表示。

英文摘要：

In this study, we explored the effects of soy isoflavone extracts on the growth of estrogen-dependent human breast cancer （MCF-7） tumors implanted in ovariectomized athymic mice. The ovariectomized athymic mice were implanted with MCF-7 cells. They were fed with low, moderate and high doses of soy isoflavone extracts, at dietary concentrations of 6.25, 12.5 and 25 g/kg, respectively. The expression of ki-67 was detected by immunohistochemistry. The pS2 expression in tumors was analyzed by real-time PCR. Estrogen level in the serum was measured by chemiluminescence enzyme immunoassay. Compared with the control group, dietary soy isoflavone extracts had a significant stimulatory effect on MCF-7 tumor growth in mice （P 〈 0.05）. The ki-67 and pS2 mRNA expressions in tumors were significantly increased by 6.25 and 12.5 g/kg dose of soy isoflavone extracts （P 〈 0.05）. And, estrogen level in serum of 6.25 and 12.5 g/kg dose groups was higher than that of control group （P〉 0.05）. In conclusion, in the tested dietary concentration range soy isoflavone extracts had a stimulatory effect on tumor growth. 6.25 and 12.5 g/kg doses of soy isoflavone extracts can increase the cell proliferation in tumors and induce estrogen-responsive pS2 expression.