中文摘要：

心脏淋巴管的生理病理作用一直未引起人们的重视。但近年来,随着血管内皮生长因子受体-3（vascular endothelial growth factor receptor 3,VEGFR-3）、淋巴管内皮细胞透明质酸受体（lymphatic vessel endothelial hyaluronan receptor 1,LYVE-1）、果蝇同源基因转录因子（prospero homeobox protein 1,Prox-1）、肾小球足细胞膜黏蛋白（podoplanin）等淋巴管内皮细胞标志物的发现,心脏淋巴管的研究迅速发展。心脏淋巴管引流淋巴液,其功能异常可引起心肌水肿、动脉硬化、心律失常、间质纤维化等。深入认识心脏淋巴管的生理病理作用,对于治疗心肌梗死、改善心血管功能、预防心脏手术后并发症等有着重要意义。本文综述了心脏淋巴管的发生、分布以及与心血管疾病预后的关系。

英文摘要：

Physiopathological effects of cardiac lymphatics have been neglected for many years.Recently research on cardiac lymphatics increases greatly following discovering of specific markers of lymphatic endothelial cells such as vascular endothelial growth factor receptor 3（ VEGFR-3）,lymphatic vessel endothelial hyaluronan recepotor 1（ LYVE-1）,prospero homeobox protein 1（ Prox-1） and podoplanin. Cardiac lymphatics drain lymph and balance the fluid metabolism. Dysfunction of the lymphatic vessels contributes to lymphedema,atherosclerosis,arrhythmia and fibrosis. It is significant to explore physiopathological effects of cardiac lymphatics for treatment of myocardial infarction,improvement of cardiovascular functions and prevention of complication after heart surgery. This review summarizes development and distribution of cardiac lymphatics and their relation to prognosis of cardiovascular diseases.