中文摘要：

目的研究铁皮石斛Dendrobium officinale内生真菌Verticillium sp.KY-18中氧杂环类化合物。方法采用色谱分离技术进行分离和纯化,并根据谱学数据鉴定化合物的结构。结果从Verticillium sp.KY-18的发酵产物中分离得到13个氧杂环类化合物,分别鉴定为2,6-dihydroxy-2-methyl-7-（prop-1E-enyl）-1-benzofuran-3（2H）-one（1）、nigrosporapyrone D（2）、oosponol（3）、2-甲基-4-吡喃酮（4）、6-甲基-5-[（1E）-丁烯基]-2-吡喃酮（5）、penicisochroman D（6）、verrucosapyrone B（7）、（1S,3S）-1,8-dimethoxy-3,5-dimethyl-6-hydroxyisochroman（8）、phomopsinone A（9）、pseudohalonectrin A（10）、dictafolin-A（11）、2,3-dihydro-5,7-dihydroxy-2,6,8-trimethyl-4H-1-benzopyran-4-one（12）、2-pyrone-4,6-dicarboxylic acid（13）。结论化合物2~10为首次从该属真菌中分离得到;化合物11~13为首次从该真菌中分离得到。

英文摘要：

Objective To study the chemical constituents in the endophytic fungus Verticillium sp. KY-18, isolated from Dendrobium candidum. Methods The compounds were isolated and purified by means of chromatographic techniques and their structures were identified on the basis of spectral features. Results Thirteen known compounds belong to oxygen heterocyclic compounds, named 2, 6-dihydroxy-2-methyl-7-（prop-1E-enyl）-l-benzofuran-3 （2H）-one （1）, nigrosporapyrone D （2）, oosponol （3）, 2-methyl-4-pyrone （4）, 5-（1E-butenyl）-6-methylpyran-2-one （5）, penicisochroman D （6）, verrucosapyrone B （7）, （IS, 353-1, 8-dimethoxy-3, 5- dimethyl-6-hydroxyisochroman （8）, phomopsinone A （9）, pseudohalonectrin A （10）, dictafolin-A （11）, 2, 3-dihydro-5, 7-dihydroxy-2, 6, 8-trimethyl-4H-l-benzopyran-4-one （12）, and 2-pyrone-4, 6-dicarboxylic acid （13）. Conclusion Compounds 2--10 are first isolated from the plants of Verticillium genus, and compounds 11--13 are first obtained from fungi.