中文摘要：

瞄准：为了评估四的效果，外科手术前的 transcatheter 打动脉的 chemoembolization (不作声) 在 hepatocellular 的 angiogenesis 上癌(HCC ) 房间。方法：有 HCC 的 136 个病人的一个总数经历了肝切除术。一～五堂功课在肝以前不作声切除术在 79 个病人被执行(不作声组) ，在哪个到四，化疗的功课独自在 11 个病人(组 A ) 被执行；与用碘处理的油相结合的化疗的一～五堂功课在 33 个病人(组 B ) 被执行；与用碘处理的油和明胶海绵相结合的化疗的一～三堂功课在 23 个病人(组 C ) 被执行；与用碘处理的油，乙醇和明胶海绵相结合的化疗的一～三堂功课在 12 个病人(组 D ) 被执行。另外的 57 个病人仅仅收到了肝切除术(非不作声的组) 。微容器被 CD31 标记。CD31 和脉管的 endothelial 生长因素(VEGF ) 的表示蛋白质被免疫检测组织化学的方法。结果：在 HCC 房间的吝啬的微容器密度(MVD ) 在比在非不作声的组的组 A， B， C 和 D 是显著地更高的(P 【 0.05 ) 。在 HCC 房间的 VEGF 蛋白质的表示在比在非不作声的组的组 A， B， C 和 D 是显著地更高的(P 【 0.05 ) 。MVD 和 VEGF 蛋白质的表示断然被相关。吝啬的 MVD 和 VEGF 蛋白质的表示是仔细与数字 of courses 有关不作声并且间隔不作声。结论：四种不同类型外科手术前不作声政体在 HCC 房间提高了 angiogenesis 由起来调整 VEGF 的表示蛋白质。镇压是必要的肝癌症在以后的 angiogenesis 不作声。

英文摘要：

AIM： To evaluate the effects of four types of preoperative transcatheter arterial chemoembolization （TACE） on angiogenesis of hepatocellular carcinoma （HCC） ceils. METHODS： A total of 136 patients with HCC underwent liver resection. One to five courses of TACE prior to liver resection were performed in 79 patients （TACE group）, in which one to four courses of chemotherapy alone were performed in 11 patients （group A）; one to five courses of chemotherapy combined with iodized oil were performed in 33 patients （group B）; one to three courses of chemotherapy combined with iodized oil and gelatin sponge were performed in 23 patients （group C）, one to three courses of chemotherapy combined with iodized oil, ethanol and gelatin sponge were performed in 12 patients （group D）. The other 57 patients only received liver resection （non-TACE group）. The microvessels were marked by CD31. The expression of CD31 and vascular endothelial growth factor （VEGF） protein were detected by immunohistochemical methods. RESULTS： The mean microvessel density （MVD） in HCC cells was significantly higher in groups A, B, C and D than in the nonACE group （P 〈 0.05）. The expression of VEGF protein in HCC cells were significantly higher in groups A, B, C and D than in the non-TACE group （P 〈 0.05）. MVD and the expression of VEGF protein were positively correlated. Mean MVD and the expression of VEGF protein were closely related to the number of courses of TACE and the interval of TACE. CONCLUSION： Four different types of preoperative TACE regimens enhanced angiogenesis in HCC cells by up-regulating the expression of VEGF protein. It is necessary to repress angiogenesis of liver cancer after TACE.