Selenium Supplementation Alleviates Autoimmune Thyroiditis by Regulating Expression of Thl/Th2 Cytokines
- ISSN号:1004-0374
- 期刊名称:《生命科学》
- 时间:0
- 分类:Q2[生物学—细胞生物学] Q591.5[生物学—生物化学]
- 作者机构:[1]Nutrition and Food Security Department, College of Public Health, Tianjin Medical University, 22 Qixiangtai Road,Heping District, Tianjin 300070, China, [2]Sanitary Chemistry Department, College of Public Health, Tianjin MedicalUniversity, 22 Qixiangtai Road, Heping District, Tianjin 300070, China
- 相关基金:supported by three programs from the National Natural Science Foundation of China (NSFC) (The experimental study on the effect of trace elements iodine and selenium on the autoimmune thyroid disease (No.30571564);The cross-sectional investigation on hypothyroidism induced by excess iodine intake and the experimental research on pathogenesy (No.30972465);The change of thyroid pathology and the levels of T3,T4 in SePP1,GPX3 knock out mice (No.30810103004)
中文摘要:
<正>Selenium (Se) is an essential trace element.Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens.However,the effects of Se on the cytokines in AITD are still unclear.So we researched the role of Selenium (Se) and Th1/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).The data shown that high Se intake reduced the autoantibody titers and alleviated the pathological
英文摘要:
Selenium (Se) is an essential trace element. Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens. However, the effects of Se on the cytokines in AITD are still unclear. So we researched the role of Selenium (Se) and Thl/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).