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针刺治疗强迫症的临床随机对照研究
  • 期刊名称:中华中医药杂志(原中国医药学报)
  • 时间:2014.8
  • 页码:2686-2690
  • 分类:R969.4[医药卫生—药理学;医药卫生—药学]
  • 作者机构:[1]广州中医药大学第二临床医学院,广州510405, [2]番禺嘉和门诊部,广州511447, [3]广东省中医院针灸科,广州510120
  • 相关基金:广东省科技支撑项目(No.2008B030301206);国家自然科学基金项目(No.81173348)
  • 相关项目:基于胶质细胞介导谷氨酸循环的针刺抗抑郁机理研究
中文摘要:

目的:观察针刺优化方案治疗强迫症的临床疗效。方法:采用随机单盲对照试验,将70例符合CCMD-3诊断以及耶鲁-布朗强迫量表(Y-BOCS)大于16分的患者按1:1随机分为常规方案组(对照组)和优化方案组(治疗组)。患者每周治疗2次,疗程为10周。疗程结束后以汉密尔顿抑郁量表(HAMD)和Y-BOCS评价两组方案治疗强迫症的临床疗效。结果:70例患者中,5例患者未能完成治疗,其中剔除1例,脱落4例。治疗结束后,两组HAMD和Y-BOCS评分均较治疗前下降,治疗组较对照组下降明显,差异有统计学意义(P〈0.05)。结论:常规方案与优化方案均对强迫症有较好的临床疗效,优化方案在改善强迫症上优于常规方案。

英文摘要:

Objective: To evaluate its clinical efficacy of an optimized acupuncture formula for obsessive compulsive disorder. Methods: This was a randomized, subject-and assessor-blind, parallel-group trial. 70 subjects who met the CCMD-3 diagnosed criteria, defined as a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score 〉 16 were randomly assigned to either conventional acupuncture formula group (control group) or optimized acupuncture formula group (treatment group) in ratio of 1:1. Curative effects were evaluated by using Hamilton rating scale (HAMD) and Y-BOCS. Participants received two sessions weekly for ten weeks. Results: Of the 70 subjects, 5 subjects didn't complete the study, while 1 were withdrew and 4 dropped out. There was significant reduction in Y-BOCS score from base line to the end of treatment in both groups. Patients who received optimized acupuncture experienced a greater rate of decrease in Y-BOCS (P〈0.05) compared with the conventional acupuncture. As to HAMD score, They also had significantly greater response rate of reduction (P〈0.05) compared with the conventional acupuncture. Conclusion: Our study suggested that both conventional acupuncture formula optimized acupuncture formula were effective for obsessive compulsive disorder. The optimized acupuncture formula had better effect on treating obsessive compulsive disorder.

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