中文摘要：

将蟾蜍与小鼠分别分为实验组与对照组。实验组给予足跖皮肤针刺刺激,检测二者延髓平髓纹水平Ⅳ脑室周围神经元Fos蛋白的阳性表达情况。结果表明：蟾蜍实验组和对照组Fos阳性神经元数量均很多,组间差异无统计学意义;小鼠实验组Fos阳性神经元显著多于对照组（p〈0.01）;与蟾蜍比较,小鼠实验组和对照组Fos阳性神经元数量均显著少于蟾蜍（p〈0.05,p〈0.01）。提示蟾蜍和小鼠Ⅳ脑室周围神经元对足跖部皮肤的针刺刺激的敏感度不同。

英文摘要：

The comparison of the Fos expressions of medulla neurons in toad and mouse were made. Toads and mice were separately divided into two groups ： experimental group and control group. Gave the acupuncture stimulation to the skin of posterior limb vola pedis of the experimental animals,the control group animals were not given stimulation. The amount of Fos positive neurons around the IV ventricle fiat stria medullaris level in both of animals were determined by using immunohistochemical method. For toad, both the experimental group and the control group, there are a lot of Fos positive neurons in medulla, the differences between the two groups have no statistically significance. For mouse, compared with toads, both the experimental group and the control group, the amount of Fos positive neurons were significantly lower than toads （p 〈0. 05, p 〈 0.01 ） ; the amount of Fos positive neurons in the experimental group was significantly higher than that of the control group （p 〈 0. 01 ）. These results indicate that the neurons around the 1V ventricle in toad＇ s medulla are not sensitive to the acupuncture stimulation of the skin of posterior limb vola pedis and the mice are sensitive. The higher mammals may be due to the encephalization, the number of neurons in medulla in response to noxious stimulation of the skin is instead fewer than that of the lower vertebrates.