中文摘要：

目的：探讨乌司他丁联合山莨菪碱在创伤性肺损伤治疗过程中的临床治疗效果。方法：选取2011年1月-2013年1月本院收治的100例创伤性肺损伤患者的临床资料,按照随机数字表法将所有患者分为A、B、C、D组各25例。其中A组给予常规治疗,B组给予乌司他丁治疗,C组给予山莨菪碱治疗,D组给予乌司他丁联合山莨菪碱治疗。观察比较四组患者的氧合指数、机械通气时间,ICU住院时间、治疗后ARDS发生率、治疗有效率和血清TNF-α与IL-6水平。结果：D组机械通气时间、ICU住院时间均明显少于其他三组,四组治疗后的氧合指数均明显高于治疗前,且D组的氧合指数明显高于其他三组；D组治疗后的ARDS发生率明显低于A组,差异有统计学意义（P〈0.05）。治疗前四组患者的血清TNF-α与IL-6水平比较差异均无统计学意义（P〉0.05）,治疗后四组患者的血清TNF-α与IL-6水平均明显低于治疗前,D组治疗后血清TNF-α与IL-6水平均明显低于其他三组,但D组治疗有效率88.0%明显高于其他三组,差异均有统计学意义（P〈0.05）。结论：在创伤性肺损伤治疗、控制过程中,乌司他丁联合山莨菪碱的临床治疗效果显著,多药合用有效发挥药物协同作用,有效降低患者炎性因子释放,降低患者ICU住院时间与病死率,值得进一步研究推广。

英文摘要：

Objective：To investigate the efficacy of Ulinastatin combined with Anisodamine in the treatment of traumatic lung injury.Method：The clinical data of 100 patients with traumatic lung injury in our hospital from January 2011 to January 2013 were selected,they were randomly divided into the group A,group B,group C and group D,25 cases in each group.The group A was given conventional therapy,the group B was treated with Ulinastatin,the group C was treated with Anisodamine,the group C wa treated with Ulinastatin combined with Anisodamine.Oxygenation index, duration of mechanical ventilation,ICU stay,the incidence of ARDS after treatment,the effective rate of treatment and serum TNF-α and IL-6 levels of four groups were observed and compared.Result：The duration of mechanical ventilation and ICU stay of the group D were significantly less than the other three groups,oxygenation index after treatment of the four groups were significantly higher than that before treatment,and oxygenation index of the group D was significantly higher than the other three groups;after treatment,the incidence of ARDS in group D was significantly lower than group A,the difference was statistically significant（P〈0.05）.There were no significant differences among four groups in serum TNF-α and IL-6 before treatment.After treatment,serum TNF-α and IL-6 of the four groups were significantly lower than before treatment,after treatment in group D,serum TNF-α and IL-6 levels were significantly lower than the other three groups,but the treatment efficiency of the group D （88.0%） was significantly higher than the other three groups, the differences were statistically significant（P〈0.05）.Conclusion：In the treatment and control process of traumatic acute lung injury,the clinical therapeutic effect of Ulinastatin combined with Anisodamine is significantly,many drugs exert synergistic effect,effectively reduce the release of inflammatory factors,reduce hospitalization time and mortality rate,worthy of further research and promot