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吴茱萸碱对大鼠下丘脑弓状核NPYmRNA的影响
  • 分类：R285.5[医药卫生—中药学;医药卫生—中医学]
  • 作者机构：[1]陕西中医学院医学技术系,陕西咸阳712046, [2]西安交大医学院生理与病理生理系,陕西西安710061, [3]西安交大附属二院消化科,陕西西安710004
  • 相关基金：国家自然科学基金资助项目（30670691）
作者： 施京红[1], 闫剑群[2], 丁辉[3]
关键词： 吴茱萸碱, NPY, 实验研究
中文摘要：

目的研究吴茱萸碱（evodiamine，Evo）对大鼠下丘脑弓状核神经肽Y（neuropeptideY，NPY）基因表达水平的影响。方法采用荧光实时定量PCR（Real—TimePeR）的方法，观察Evo干预后下丘脑弓状核促食欲肽NPYmRNA的表达，探讨吴茱萸碱在大鼠体重控制中的可能机制。结景吴茱萸碱40ms／kg灌胃干预后，下丘脑弓状核NPY基因水平显著降低。结论Evo可降低大鼠下丘脑弓状核促食欲肽NPYmRNA水平，提示下丘脑可能是Evo调节摄食行为的重要中枢。

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