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miR-34a在新疆维吾尔族和汉族妇女不同宫颈病变组织中的表达及临床意义
  • ISSN号:1004-616X
  • 期刊名称:癌变.畸变.突变
  • 时间:2016.1
  • 页码:585-590
  • 分类:R719.83[医药卫生—妇产科学;医药卫生—临床医学]
  • 作者机构:新疆医科大学第一附属医院妇科,乌鲁木齐830054
  • 相关基金:国家自然科学基金资助项目(No:81160278)
  • 相关项目:MicroRNA与新疆维、汉宫颈癌发病机制及病理生物学关系的研究
中文摘要:

目的:系统评价生物可吸收防粘连膜预防术后盆腹腔粘连的有效性及安全性。方法:计算机全面检索Pub Med数据库、Spring数据库、OVID数据库、CBM数据库、CNKI数据库、万方数据库,查找关于生物可吸收防粘连膜(HC-CMC)预防术后盆腹腔粘连的有效性及安全性的随机对照文献,检索时限2000年2月至2015年3月。按纳入和排除标准进行文献筛选、资料提取和质量评价后,采用Rev Man 5.3软件进行Meta分析。结果:最终共纳入7篇RCT文章。Meta分析结果显示,试验组与对照组的术后盆腹腔粘连、粘连严重程度2级和3级、粘连范围2级和3级的发生率比较,差异均有统计学意义;粘连严重程度1级和粘连范围1级的发生率比较,差异均无统计学意义(P=0.82,P=0.1)。试验组与对照组的术中出血量比较,差异有统计学意义(P〈0.00001);而术后肠梗阻、盆腹腔脓肿、伤口感染、高热的发生率比较,差异均无统计学意义。结论:手术中应用生物可吸收防粘连膜可降低盆腹腔粘连的发生率,减轻粘连严重程度,减少粘连范围,减少术中出血量,然而术后肠梗阻、盆腹腔脓肿、伤口感染及术后高热的发生率相似。

英文摘要:

Objective: To assess the clinical effectiveness and safety of biological adsorbable anti adhesion membrane in preventing postoperative abdominopelvic adhesions. Methods: The following databases such as Pub Med、Spring、OVID、CBM、CNKI、Wanfang data were searched to collect the randomized control trails( RCTs) about the clinical effectiveness and safety of biological adsorbable anti adhesion membrane( HC-CMC) in preventing postoperative abdominopelvic adhesions.According to the inclusion and exclusion criteria to search studies,extracted data,and evaluated the methodological quality.The meta-analysis was performed using Rev Man software version 5.3.Results: Seven RCTs were included.In the aspect of validity,metaanalyses showed that compared with the control gruop,The incidence of adhesions have statistical significance( P〈0.00001). The incidence of adhesions degree level2,level3 have statistical significance.The incidence of adhesions degree level 1 have no statistical significance( P = 0.82).The incidence of adhesions scope level 2,level 3 have statistical significance.The incidence of adhesions scope level 1 have no statistical significance( P = 0.1). Meta-analyses showed that compared with the control gruop,the intraoperatve blood loss have statistical significance( P〈0.00001). Postoperative intestinal obstruction,abdominal abscess,the incidence of wound infection,high fever were not statistically significant. Conclusion: Application of adsorbable anti adhesion membrane in the operation can reduce the incidence of abdominopelvic adhesion,reduce the degree of adhesion,reduce the scope of adhesion,reduce the intraoperatve blood loss. But the abdominal abscess,intestinal obstruction,wound infection and the incidence of postoperative adverse reaction such as high fever is similar.

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期刊信息
  • 《癌变.畸变.突变》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国环境诱变剂学会
  • 主编:程书钧
  • 地址:广东省汕头市新陵路22号汕头大学医学院
  • 邮编:515041
  • 邮箱:office@egh.net.cn
  • 电话:0754-88900267
  • 国际标准刊号:ISSN:1004-616X
  • 国内统一刊号:ISSN:44-1063/R
  • 邮发代号:80-285
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),中国中国科技核心期刊
  • 被引量:6443