过氧化物酶体增殖物激活受体(peroxisome proliferators-activated receptors,PPARs)是配体激活的转录因子,属于核受体超家族成员。PPARs有3种亚型,即PPARα(NR1C1)、PPARβ/δ(NUC1;NRIC2)和PPARγ(NR1C3)。大量研究表明PPARs广泛参与机体的脂质代谢、糖代谢、能量代谢、血压调节、细胞生长分化及生殖过程,并在炎症过程中发挥重要的作用。近年来,PPARβ/δ在炎症发生中的作用及其调控机制日益受到人们的关注,该文对PPARβ/δ在炎症发生中的作用作一综述。
Peroxisome proliferators-activated receptors (PPARs) are transcriptional factors belonging to the ligand-activated nuclear receptor superfamily. So far, three major PPAR subtypes have been identified,which are named PPARβ/δ( NR1C1 ),PPARβ/δ (NUC1 ; NR1C2) and PPARγ( NR1C3 ), respectively. PPARs play important roles in the regulation of lipid and glucose metabolism, energy homeostasis, blood pressure control, cell proliferation and differentiation. In addition, increasing evidence reveals that PPARs are involved in the regulation of various types of inflammation. In the current paper, the role of PPARβ/δin inflammation and its underlying mechanisms will be briefly reviewed and discussed.