中文摘要：

目的：通过观察茵陈蒿汤和甘露消毒丹对二甲基亚硝胺（DMN）诱导的大鼠肝纤维化模型的效应,探讨该模型的证候病机。方法：采用腹腔注射DMN 4周诱导大鼠肝纤维化,于造模第3周开始,各给药组在继续造模的同时予以茵陈蒿汤和甘露消毒丹药物干预。4周末杀鼠取材,观察药物干预效果。结果：与正常组比较,模型组出现显著的肝损伤和肝纤维化,肝组织Hyp含量显著升高（P〈0.01）,肝功能显著异常（P〈0.01）。与模型组比较,茵陈蒿汤可显著改善肝组织病理,降低肝组织Hyp含量（P〈0.01）,显著改善肝功能（P〈0.05,P〈0.01）;甘露消毒丹可显著改善肝组织病理,降低肝组织Hyp含量（P〈0.01）,显著降低血清总胆红素（TBil）含量（P〈0.01）,但对血清ALT、AST和ALB等的作用不明显。结论：茵陈蒿汤对DMN诱导的大鼠肝纤维化模型的治疗效果显著优于甘露消毒丹;DMN诱导的大鼠肝纤维化模型在其形成期的病机以＂湿（瘀）热内蕴＂为主,且湿（瘀）热并重,与茵陈蒿汤方证高度相关。

英文摘要：

Objective： To explore the recipe-syndrome correlation of Yinchenhao Tang （YCHT） and Ganluxiaodu Dan （GLXDD） on inhibition of liver fibrosis induced by dimethylnitrosamine in rats. Methods： Rats were randomized into four groups： normal control, DMN-, YCHT-, and GLXDD groups. Liver fibrosis model was induced by dimethy nitrosamine （DMN） intra- peritoneally injection for 4 weeks at the dosage of 10 mg/kg body weight, once per day for 3 consecutive days in each week in rats. Each of groups was gastric infused respectively with distilled water （control or model group）, YCHT group and GLXDD in the continuous 2-week modeling period. At the end of the 4th week, rats were sacrificed and their blood sample and liver tissue were gotten for detection. Results： Liver fibrosis induced by DMN in rats was improved by administration of YCHT. YCHT treatment for 2 weeks, content of Hyp was decreased remarkably （P〈0.01） and liver function and hepatic histology were improved significantly （P〈0.05, P〈0.01）; while those effects on ALT, AST and ALB were not shown in the GLXDD groups. Comparisons of various parameters between groups showed that contents of serum total bilirubin （TBil） and hepatic Hyp were decreased significantly （P〈0.01） and hepatic histology was improved significantly in the GLXDD group. Conclusion： Efficacy of YCHT inhibition of liver fibrosis induced by DMN in rats was far better than GLXDD. The syndrome-pathogenesis of the liver fibrosis model induced by DMN in rats was damp （stagnate） heat syndrome. Damp （stagnate） and heat pathogenic factor were both the core role pathogenesis in this model.