目的:确定白介素-9(IL-9)和白介素-10(IL-10)基因拷贝数与银屑病发病的相关性。方法:采用RT-PCR对424例银屑病患者和424名健康者的IL-9和IL-10基因拷贝数变异进行检测和比较。结果:银屑病患者的IL-9和IL-10基因拷贝数较健康人基因拷贝数显著增高(P〈0.05)。结论:IL-9和IL-10基因拷贝数增加可能会增加对银屑病的易感性。
Objective: To determine the association of interleukin-9 (IL-9) and interleukin- 10 ( IL- 10) gene copy number variations with psoriasis. Methods: Determination of gene copy number of IL-9 and IL-10 was achieved by RT-PCR method and compared between 424 psoriatic patients and 424 healthy controls. Re suits: The IL-9 and IL-10 gene copy number was higher in the psoriatic patients than in the healthy controls (P〈0.05). Conclusion: The increasing of IL-9 and IL-10 gene copy numbers may increase the susceptibili ty to psoriasis.