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Clinical and pathological analysis on Traditional Chinese Medicine syndromes in children with immunoglobulin A nephropathy

ISSN号：1006-3757
期刊名称：《分析测试技术与仪器》
时间：0
分类：S858[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医] O636[理学—高分子化学;理学—化学]
作者机构：[1]Traditional Chinese Medicine department, Beijing Children's Hospital Affiliated to Capital Medical University,Beijing 100045, China, [2]Renal department, Beijing Children'sHospital Affiliated to Capital Medical University, Beijing100045, China, [3]Pathology department, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing100045, China
相关基金：Supported by the Project of Capital Medical Development Fund（TCMType,SF-2007Ⅱ -07）

作者： Xue Shi[1], Nan Zhou[2], Chunju Zhou[3], Ying Shen[2]

关键词： IgA肾病, 中医证候, 临床表现, 病理分析, 传统医药, 儿童, 中国, 蛋白A, Glomerulonephritis,Immunoglobulin A, Children, Urination disorders, Qi deficiency of spleen and lung

中文摘要：

评估普通繁体中文药(TCM ) 的目的症候群和分析他们的关系到在有 IgA nephropathy 的孩子的临床、病理学的表明。作为第一次由肾的活体检视有主要 IgA nephropathy 诊断的四十五个孩子在这试用被注册的方法，和他们的 TCM 症候群被评估， TCM 症候群的分发被观察。所有病了的孩子被养吗？根据临床的表明和病理学的损坏，并且在 TCM 症候群的差别在这些组之间被比较。结果开始的 5 TCM 症状是普通感冒，剧汗，红干燥喉咙，黑暗的黄尿和疲乏。在尖锐肾炎组，在腰和膝的浮肿和疼痛疼痛是重要的(P=0.021 和 P=0.000 ) 。在严重病理学的损坏组，浮肿是明显的(P= 0.004 ) ，并且 24 h 尿蛋白质断然与浮肿(P=0.015 ) 被相关当时否定地与普通感冒(P=0,007 ) 。mesangial 房间增长的分数与浮肿，红干燥喉咙和普通感冒被相关(P=0.006， 0.013 和 0.029 分别地) 。部分病理学的变化的分数断然与浮肿(P=0.039 ) 被相关。结论普通感冒，剧汗，红干燥喉咙，黑暗的黄尿，疲乏和主要与 IgA nephropathy 在孩子看见的怒气和肺的 qi 缺乏的另外的症状可以忍受一种靠近的关系到临床的表明和病理学的损坏。

英文摘要：

OBJECTIVE：To evaluate the common Traditional Chinese Medicine（TCM） syndromes and analyze their relationship to clinical and pathological manifestations in children with IgAnephropathy.METHODS：Forty five children diagnosed as having primary IgA nephropathy by renal biopsy for the first time were enrolled in this trial,and their TCM syndromes were evaluated and the distribution of TCM syndromes was observed.All the sick children were growed？ according to clinical manifestations and pathological damages,and the differences in TCM syndromes were compared between the groups.RESULTS：The first 5 TCM symptoms were common cold,hyperhidrosis,red dry throat,dark yellow urine and lassitude.In the acute nephritis group,edema and aching pain in loin and knees were significant（P=0.021 and P=0.000）.In the severe pathological damage group,edema was obvious（P= 0.004）,and 24 h urinary protein was positively correlated with edema（P=0.015） while negatively with common cold（P=0,007）.The score of mesangial cell proliferation was correlated with edema,red dry throat and common cold（P=0.006,0.013 and 0.029 respectively）.The score of segmental pathological change was positively correlated with edema（P=0.039）.CONCLUSION：Common cold,hyperhidrosis,red dry throat,dark yellow urine,lassitude and other symptoms of qi deficiency of the spleen and lung mainly seen in children with IgA nephropathy may bear a close relationship to clinical manifestations and pathological damages.

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