抗血管生成已经成为治疗肿瘤转移、糖尿病视网膜病变、风湿性关节炎等疾病的重要策略之一。血管生成模型作为一种研究工具在探讨血管形成机制、发现促进或抑制血管生成药物等研究中发挥十分积极的作用。如何寻找适合的血管生成模型是研究人员在研究中常遇到的问题。该文就主要常用模型做较全面的介绍,并对其优缺点进行评价。
Anti-angiogenesis has been one of the important strategies in treating tumor metastasis, diabetic retinopathy, rheumatic arthritis etc. Angiogenesis models have played an active role in studying the mechanism of angiogenesis and developing drugs of pro- or anti-angiogenesis. A common problem faced by angiogenesis researchers has been the difficulty of choosing suitable models. This paper reviews principal models in use for some details and their advantages and shortages.