中文摘要：

目前强制性运动疗法广泛地应用于康复领域，并被证实能够有效促进脑缺血后肢体运动功能的恢复。功能磁共振成像和经颅磁刺激等神经影像技术证明，强制性运动疗法能够促进脑缺血后功能重组，影响神经再生。强制性运动疗法通过上调间质细胞源性因子-1（SDF-1）来增强内源性神经干细胞的激活，而SDF-1又通过抑制Rho激酶的活性来促进神经元轴突延伸。抑制Rho激酶活性还会消除勿动蛋白（Nogo）受体介导的抑制作用从而促进轴突再生，进而明显改善神经功能缺失？因此，SDF-1、Nogo及Rho激酶可能是强制性运动疗法促使脑缺血后神经再生的重要分子．

英文摘要：

At present, constraint - induced movement therapy （CIMT） is extensively applied to the area of rehabilita- tion, and is confirmed to be able to efficiently promote motor recovery after cerebral ischemia. The functional remodeling of cerebral cortex and neuranagenesis ＇after cerebral ischemia by CIMT can complement the function of injured tissues, which has been confirmed by functional neuroimaging techniques. CIMT can activate endogenous nerve stem cells by upregulating strornal cellderived factor - 1 （ SDF - 1 ） , and SDF - 1 facilitates axon anagenesis by inhibiting the activity of Rho kinase. Inhibiting the activity of Rho kinase can also eliminate depressant effect mediated by Nogo receptor. Therefore, SDF - 1, Nogo and Rho kinase are probably significant molecules that facilitate neuranagenesis after cerebral ischemia with CIMT.