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非肥胖性糖尿病（NOD）小鼠模型及其发病免疫学机制
  • ISSN号：1000-3282
  • 期刊名称：《生物化学与生物物理进展》
  • 时间：0
  • 分类：R-332[医药卫生]
  • 作者机构：[1]中国科学院动物研究所生物膜与膜生物工程国家重点实验室移植生物学研究组,北京100080
  • 相关基金：中国科学院引进海外杰出人才百人计划资助项目（2003）,国家杰出青年基金项目（NO.30425026）,中国博士后基金项目（30020040300）,中国科学院王宽诚博士后科研奖励基金（2004）项目资助.
作者： 马海霞[1], 刘光伟[1], 赵勇[1]
关键词： 免疫耐受, 调节性T细胞, T细胞信号, 非肥胖性糖尿病小鼠
中文摘要：

非肥胖性糖尿病（non-obese diabetic，NOD）小鼠是一种被广泛应用的自身免疫性1型糖尿病（type 1 diabetes，T1D）小鼠。20多年以来，这一品系为我们研究自身免疫病复杂的过程提供了重要的研究依据。自身免疫病被认为是由中枢或外周免疫耐受网络缺陷而引起的疾病。本文重点叙述最近对中枢和外周免疫耐受通路缺陷方面的研究进展以及这些进展对治疗自身免疫性糖尿病的影响。

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期刊信息
  • 《生物化学与生物物理进展》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国科学院生物物理研究所 中国生物物理学会
  • 主编：王大成
  • 地址：北京市朝阳区大屯路15号
  • 邮编：100101
  • 邮箱：prog@sun5.ibp.ac.cn
  • 电话：010-64888459
  • 国际标准刊号：ISSN：1000-3282
  • 国内统一刊号：ISSN：11-2161/Q
  • 邮发代号:2-816
  • 获奖情况:
  • 1999年中国期刊奖提名奖,2000年中国科学院优秀期刊特别奖
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国剑桥科学文摘,美国科学引文索引（扩展库）,美国生物科学数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:18821