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A soluble polymer-supported NADH model: Synthesis and application
  • ISSN号：1001-6538
  • 期刊名称：Chinese Science Bulletin
  • 时间：0
  • 页码：2824-2828
  • 分类：TQ426.65[化学工程] Q552[生物学—生物化学]
  • 作者机构：[1]Department of Chemistry and the State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
  • 相关基金：This paper is dedicated to Professor LIU YouCheng on the occasion of his 90th birthday. This work was supported by the National Basic Research Program of China （2004CB719905）, the National Natural Science Foundation of China （20832004, 20472038, 20721062 and 20672060） and the 111 Project （B06005）.
  • 相关项目：有机负氢化合物中的物理有机化学问题
作者： Mei LianRui|Zhu Xiao-Qing|Cheng Jin-Pei|
关键词： 辅酶模型, 可溶性聚合物, 合成, 应用, 聚乙二醇, 有机还原剂, NADH, 环境温度, hydride, reduction, NADH model, solvent.free, recyclable, polyethylene glycol （PEG）
中文摘要：

当新奇器官的 reductant 被设计并且综合，聚乙烯乙二醇(木钉) 支持了 NADH 模型。由支持木钉的 NADH 模型的各种各样的、不饱和的酉同类的减小被检验，并且结果证明减小完全并且快速在周围的温度没有催化剂继续。这个像液体的支持木钉的 NADH 模型的主要优点为再循环使用是容易的 workup，和一个最佳的潜力并且为在反应的使用没有溶剂。

英文摘要：

A polyethylene glycol （PEG）-supported NADH model as a novel organic reductant was designed and synthesized. The reductions of various α, β-unsaturated ketones by the PEG-supported NADH model were examined, and the results showed that the reduc- tions completely and quickly proceed with no catalyst at ambient temperature. The main advantages of this liquid-like PEG-supported NADH model are easy workup, and an optimal potential for recycling use and solvent-free for use in reactions.

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