中文摘要：

目的：建立同时测定天宁滴丸中天麻素和阿魏酸溶出度的方法。方法：选用小杯法，以0．1mol·L^-1盐酸为溶出介质，转速为50r·min^-1，用高效液相色谱法测定天麻素、阿魏酸的溶出度，绘制溶出曲线，计算溶出参数T50、Td、m，并用相似因子法进行评价。结果：天麻素、阿魏酸的检测浓度分别在0．0118-0．1180mg·mL^-1（r=0．9992）、0．0048-0．0480mg·mL^-1（r=0．9996）范围内与各自的峰面积积分值呈良好的线性关系；天麻素的平均回收率为97．96％（RSD=2．06％），阿魏酸的平均回收率为98．10％（RSD=2．26％）。3批样品溶出度相似。结论：本方法简便、准确、可靠，能同时测定天宁滴丸中2组分的溶出度。

英文摘要：

OBJECTIVE： To determine the dissolution rates of Gastrodin and Ferulic acid in Tianning drop pills simultaneously. METHODS： The small glass cup method was adopted in which 0.1 mol·L^- 1 hydrochloric acid was taken as solvent with a rotating speed of 50 r · min^-1. The dissolution rates of Gastrodin and Ferulic acid were determined by HPLC. The dissolution curves were drawn, and the dissolution parameters including T50, Td, and m were computed and evaluated using similar factors method. RESULTS： The Gastrodin and Ferulic acid were linear over the range of 0.011 8-0.118 0 mg · mL^-1 （ r = 0.999 2） and 0.004 8-0.048 0 mg · mL^-1（ r = 0.999 6）, respectively. The average recoveries of the two ingredients were 97.96% （RSD = 2.06% ） and 98.10% （RSD = 2.26% ）, respectively. The three batches samples were proved to be of similar dissolution rates. CONCLUSION： The determination method is simple, accurate and reliable, which can be applied to determine the dissolution rates of gastrodin and ferulic acid in Tianning drop pills simultaneously.