中文摘要：

目的探讨氟比洛芬酯对下肢骨折患者血浆可溶性细胞间黏附分子-1（sICAM-1）表达和术后疼痛的影响。方法60例下肢骨折择期拟行手术治疗的患者随机分为对照组（C组）和氟比洛芬酯组（F组），每组30例。2组均采用硬膜外麻醉，给药方法一致。氟比洛芬酯组硬膜外给药前静脉注射氟比洛芬酯1mg／kg。监测2组患者麻醉前、麻醉后2h的脉搏氧饱和度（SpO2）、心率（HR）、收缩压（SBP）、舒张压（DBP）的变化，酶联免疫吸附法（ELISA）测定麻醉前、麻醉后2h、术后4h血浆sICAM-1的表达，视觉模拟评分法（VAS）评估患者术后1、6、12、24h的疼痛感觉程度。结果2组患者一般资料比较差异无统计学意义（P〉0．05）；2组患者各时点SBP、DBP、HR、SpO2比较差异无统计学意义（P〉0．05）；与麻醉前比较，2组患者麻醉后2h、术后4h血浆sICAM-1的表达均增加；与C组比较，F组患者麻醉后2h、术后4h血浆sICAM～1的表达以及术后1、6、12、24h的VAS评分均降低（P〈0．05）。结论氟比洛芬酯抑制下肢骨折患者血浆sICAM-1的表达，具有一定的抗炎作用，并可以减轻患者的术后疼痛。

英文摘要：

Objective To investigate the effects of flurbiprofen axetil on the level of plasma soluble intercellular adhesion molecule - 1 （sICAM - 1 ） and postoperative pain in patients with lower limb fracture. Methods A total of 60 patients who were scheduled to receive surgical treatment due to acute lower limb fracture were randomly divided into two groups （ n = 30） ： a control group （ Group C） and a flurbiprofen axetil group （ Group F）. All patients were subject to epidural anesthesia through the same route of adminiatration. Patients in Group F were intravenously injected with 1 mg/kg flurbiprofen axetil before epidural administration. The changes in their systolic blood pressure （SBP）, diastolic blood pressure （ DBP）, heart rate （HR） and oxygen saturation （ SpO2 ） were recorded before anesthesia and 2 h after anesthesia. The level of plasma slCAM - 1 was evaluated by ELISA before anesthesia, 2 h after anesthesia and 4 h after operation. The visual analog scale （VAS） was assessed at 1, 6, 12 and 24 h after operation. Results No statistical difference was found as to age, gender, weight, the time of operation and the degree of trauma among the two groups （P 〉 0.05）. No statistical difference was found as to SBP, DBP, HR, SpO2 at each points （P 〉 0.05 ）. The level of plasma sICAM - 1 was higher 2 h after anesthesia and 4 h after operation, compared with that before anesthesia. Compared with the Group C, the amount of plasma sICAM - 1 was decreased 2 h after anesthesia and 4 h after operation. Meanwhile, the VAS was reduced at 1 h, 6 h, 12 h and 24 h after operation in Group F, compared with Group C P 〈0.05）. Conclusions Flurbiprofen axetil may inhibit the expression of plasma sICAM - 1, and produce anti - inflammatory effects and can relieve postoperative pain in patients with lower limb fracture.