中文摘要：

目的：探讨创伤性颅脑外伤患者脑脊液中代谢谱的改变及其临床意义。方法：用高分辨率质子核磁共振代谢组学检验创伤性颅脑损伤对脑化学物质和代谢的影响。在重型创伤性颅脑损伤组（n=6）,损伤后的脑脊液分析脑代谢的变化,并与轻,中型颅脑损伤组（n=6）相比较。结果：与轻型,中型颅脑损伤组相比,发现了乙酰乙酸,尿酸,3-硝基酪氨酸升高的证据。3组脑脊液中乙酰乙酸,尿酸,3-硝基酪氨酸含量有显著性差异（p〈0.01）。结论：颅脑创伤后脑脊液中乙酰乙酸,尿酸,3-硝基酪氨酸值均有不同程度升高,且升高越明显则病情越严重。说明乙酰乙酸,尿酸,3-硝基酪氨酸可作为颅脑创伤病情的监测指标。

英文摘要：

Objective： To study metabonomics changes and Clinical signification of CSF metabolic disturbances following traumatic brain injury. Methods： brain chemistry and metabolism were examined using high-resolution 1H NMR metabolomics of Cerebrospinal fluid . Brain injury in the Severe TBI group （n=6） were analyzed in Cerebrospinal fluid and compared with changes in Mild （n=6） and Moderate TBI group （n=6）. Results： Compared with Mild and Moderate TBI group ,evidence was found of acetoacetic acid, Uric acid and 3-Nitrotyrosine ＇s elevating , which content of cerebrospinal fluid were significantly difference in 3 groups（p〈0.01）. Conclusions： Acetoacetate , Uric acid and 3-Nitrotyrosine level all were elevated on varying degrees in cerebrospinal fluid after traumatic brain injury. Furthermore, The more obvious elevate, the more serious patient＇s condition is. It is expalain that acetoacetate Uric acid and 3-Nitrotyrosine can be used as a indicator for monitoring degree of the traumatic brain injury.