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Creep effect on cellular uptake of viral particles
  • 期刊名称:Chinese Science Bulletin
  • 时间:2014.3.3
  • 页码:-
  • 分类:Q51[生物学—生物化学]
  • 相关基金:supported by the National Natural Science Foundation of China(Grant Nos.A020307 and 11072094); the program for New Century Excellent Talents in University(NCET-10-0445)
  • 相关项目:软弹性体特异性粘附的弹性-随机-扩散模型及其在细胞粘附力学机理研究中的应用
中文摘要:

We developed a transient model for actin-based motility.Diffusion of actin monomers was included in the formulation and its influence on the speed of actin-driven cargos was examined in detail.Our results clearly demonstrated how actin polymerization accelerates cargos that are initially stationary,as well as how steady-state is eventually reached.We also found that,due to polymerization and diffusion,actin monomer concentration near the load surface can be significantly lower than that in the rest of th...

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