中文摘要：

lumichrome (LC ) 的相互作用被紫外可见的吸收，荧光光谱学，极化的荧光和粘性作为有 nucleobases， nucleosides 和 nucleic 酸的一根内长的荧光探针学习了。LC 的荧光被一系列 nucleic 酸和他们的先锋强烈熄灭。LC-nucleobase 和 LC-nucleic 酸建筑群上的媒介，温度和盐效果的影响被调查。LC-ctDNA 相互作用上的极化的荧光，热变性作用和粘性的影响被检验。结果证明 LC-ctDNA 的主要有约束力的模型包括进 DNA 螺旋链的强壮的设置。

英文摘要：

The interaction of lumichrome （LC） as an endogenous fluorescence probe with nucleobases, nucleosides and nucleic acids has been studied by UV-visible absorption, fluorescence spectroscopy, polarized fluorescence and viscosity. The fluorescence of LC was strongly quenched by a series of nucleic acids and their precursors. The influences of the medium, temperature and salt ef- fects on LC-nucleobase and LC-nucleic acid complexes were investigated. The influences of polarized fluorescence, thermal de- naturation and viscosity on LC-ctDNA interaction were examined. The results demonstrate that the main binding model of LC-ctDNA includes strong intercalating into the DNA helix chain.