中文摘要：

酸敏感离子通道（acid—sensing ion channels，ASICs）是一类胞外H＋激活的阳离子通道，属于阿米洛利敏感的上皮钠通道／退变素（epithelial Na＋ channels／degenefin，ENaC／DEG）超家族中的一员，该通道广泛分布在周围和中枢神经系统中，并且具有重要的生物学功能。近来研究表明，ASICs在类风湿关节炎发病过程中发挥着重要作用。该文对ASICs的细胞生物学特点以及ASICs在类风湿关节炎中对炎症、疼痛和软骨损伤等方面的作用进行综述。

英文摘要：

Acid-sensing ion channels （ ASICs） are cation chan-nels activated by extracellular H＋, which belong to the amilo-ride-sensitive epithelial Na＋ channels/degenerin （ ENaC/DEG ） superfamily. These channels are widely expressed in the central and peripheral nervous systems and have crucial biological func-tions. Recent studies have demonstrated that ASICs play an im-portant role in the pathogenesis of rheumatoid arthritis. This re- view concerns the cell biological characteristics of ASICs as well as its role in inflammation, pain, cartilage destruction and other aspects in rheumatoid arthritis.