位置:成果数据库 > 期刊 > 期刊详情页
Embryo implantation: A time for recalling and forwarding
  • 时间:0
  • 分类:Q492.6[生物学—生理学] Q954.46[生物学—动物学]
  • 作者机构:[1]State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China, [2]Graduate University of the Chinese Academy of Sciences, Beijing 100049, China
  • 相关基金:Supported by the National Key Basic Research and Development Program of China (Grant No. 2006CB944006) and National Natural Science Foundation of China (Grant No. 30770819)
  • 相关项目:胚泡分泌的HB-EGF在小鼠胚泡间隔分布过程中作用及机理
中文摘要:

胚胎培植的成功是向进一步的胚胎开发和怀孕结果的关键步。胚胎培植上的观察和调查一个世纪完了。知识的巨大的身体在解剖,组织学,超微结构和神经质的规定被积累了;象最近一样,在分子的发信号的深度信息,小径从 genomic 的研究得到了屏蔽的宽基因和特定的基因删除。从基本研究的知识实质地也帮助了在临床的应用开始并且改善人工的繁殖技术(艺术) 。现在,我们知道了正常胚胎培植包含胚胎的发展进培植能干的胚囊和 uter i 的同步转变进一个接受阶段。在胚囊和子宫之间的相互依赖的关系包含复杂神经质的规定和本地 paracrine, juxtacrine 相互作用。在这篇论文,我们考察考虑子宫的感受性和胚囊激活,以及一些更少的一些重要历史的调查结果讨论话题象胚胎间距那样,胚胎取向。在胚胎的过程期间,培植将帮助的详细机制上的进一步的理解治好女人不孕以及开发非类固醇避孕药的新产生。

英文摘要:

The success of embryo implantation is a critical step towards further embryo development and pregnancy outcome. The observations and investigations on embryo implantation have been over a century. A huge body of knowledge has been accumulated in anatomy, histology, ultrastructure and hormonal regulation; as well as recently in depth information about molecular signaling pathways got from studies of genomic wide gene screening and specific gene deletion. The knowledge from basic research has also substantially helped to initiate and improve the Artificial Reproductive Technology (ART) in clinical applications. Now we've known that the normal embryo implantation involves the embryo's development into an implantation-competent blastocyst and the synchronized transformation of uteri into a receptive stage. The interdependent relationship between the blastocyst and uterus involves complicated hormonal regulation and local paracrine, juxtacrine interactions. In this paper, we review some important historical findings regarding uterine receptivity and blastocyst activation, as well as some less discussed topics such as embryo spacing, embryo orientation. Further understandings on detailed mechanisms during the process of embryo implantation will help cure women infertility as well as develop new generation of non-steroids contraceptives.

同期刊论文项目
同项目期刊论文