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A New Biselector Chiral Stationary Phase Derived from Tartaric Acid and Its Enantioseparation Evaluation
  • ISSN号:1005-1511
  • 期刊名称:《合成化学》
  • 时间:0
  • 分类:O657.7[理学—分析化学;理学—化学]
  • 作者机构:[1]Key Laboratory of Green Chemical Process of Ministry of Education/Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology/Wuhan Institute of Technology, Wuhan 430073, Hubei, China, [2]Key Laboratory of Biodiesel of the Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China
  • 相关基金:Supported by the National Natural Science Foundation of China (20675061 and 50973086); the Research Project of Department of Education of Hubei Province (Z20081501)
中文摘要:

二个 chiral 选购者从酒石的酸被综合。选购者同时在 3-aminopropyl 硅石胶化上被使不能调动获得新 biselector chiral 静止阶段(CSP ) 以便在 chiral 识别能力上决定 biselector CSP 的选购者结构的影响。为比较,单个选购者的 CSP 也被准备。biselector CSP 与单个选购者的 CSP 比较显示出一个改进全面 chiral 识别能力。在 enantioseparation 期间,暂时的 diastereoisomers 被在 chiral analyte 和二个选购者之间的 complexation 多半在 biselector CSP 上形成。在二个选购者的功能的组在电子效果或在为 chiral 识别的位的阻碍者是补足的。

英文摘要:

Two chiral selectors were synthesized from tartaric acid. The selectors were simultaneously immobilized on 3-aminopropyl silica gel to obtain a new biselector chiral stationary phase (CSP) in order to determine the influence of selector structure of biselector CSPs on the chiral recognition capability. For comparison, the single-selector CSP was also prepared. The biselector CSP shows an improved overall chiral recognition capability in comparison with the single-selector CSP. During the enantioseparation, temporary diastereoisomers are likely formed by complexation between a chiral analyte and the two selectors on the biselector CSP. The functional groups in the two selectors are complementary in electronic effect and/or in steric hindrance for the chiral recognition.

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期刊信息
  • 《合成化学》
  • 中国科技核心期刊
  • 主管单位:四川省科学技术协会
  • 主办单位:四川省化学化工学会 中国科学院成都有机化学有限公司
  • 主编:熊成东
  • 地址:成都市武侯区人民南路四段9号
  • 邮编:610041
  • 邮箱:hchx@cioc.ac.cn
  • 电话:028-85255007
  • 国际标准刊号:ISSN:1005-1511
  • 国内统一刊号:ISSN:51-1427/O6
  • 邮发代号:62-196
  • 获奖情况:
  • 1998年上C.A千名表(803位),1999年入选《中国科学引文数据库》来源期刊,1999-2002年作为《中国学术期刊综合评价数据库》...
  • 国内外数据库收录:
  • 美国化学文摘(网络版),中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),英国英国皇家化学学会文摘
  • 被引量:7579